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            <title>Understanding the P-Value of Overlap Statistic in IPA</title>
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            <description>&lt;p&gt;Learn how to interpret your p-value of overlaps results in IPA. You can gain a deeper understanding of the right-tailed Fisher’s Exact Test, why it’s used in IPA, how the results are calculated, and caveats to keep in mind when interpreting your results.&lt;br&gt;For more information visit&amp;nbsp;our &lt;a href="https://www.qiagenbioinformatics.com/products/ingenuity-pathway-analysis/?cmpid=BIOX_WEB_BioX_20191605_tv.qiagenbioinformatics_Webinar_BioxBA_Must_Win_1_BIOX"&gt;&lt;u&gt;&lt;b&gt;website&lt;/b&gt;&lt;/u&gt;&lt;/a&gt;&lt;br&gt;&lt;br&gt;Sections:&lt;br&gt;&lt;div&gt;0:00-1:09 &amp;nbsp;Introduction to the video. The two types of p-values that are relevant for IPA and how they differ.&lt;/div&gt;&lt;div&gt;1:09-2:25 &amp;nbsp;History of the Fisher’s Exact Test: the “Lady Tasting Tea” experiment.&lt;/div&gt;&lt;div&gt;2:25-5:50 &amp;nbsp;Hypothesis testing for enrichment in IPA. The reference set, the null hypothesis used, and the overlap of molecules defined.&lt;/div&gt;&lt;div&gt;5:51-7:58 &amp;nbsp;Why the right-tailed Fisher’s Exact Test is used in IPA.&lt;/div&gt;&lt;div&gt;7:58- 8:41 &amp;nbsp;Explanation of sampling and expected proportions from the hypergeometric distribution.&lt;/div&gt;&lt;div&gt;8:41-9:34 &amp;nbsp;Defining significance levels in the distribution. Why only the right-tailed, rather than two-tailed test, is considered in IPA.&lt;/div&gt;&lt;div&gt;9:35-11:04 &amp;nbsp;The p-value defined and default significance level used in IPA.&lt;/div&gt;&lt;div&gt;11:04-11:12 &amp;nbsp;How the p-value is calculated. &amp;nbsp;How data is entered into the 2 x 2 contingency table and the formula used.&lt;/div&gt;&lt;div&gt;11:13-13:34 &amp;nbsp;Example calculation and interpretation using the “Lady Tasting Tea” experimental data. Why the p-value of overlap calculations are Exact.&lt;/div&gt;&lt;div&gt;13:35-15:09 &amp;nbsp;Transcriptomics example: Number of molecules tested and how they are categorized.&lt;/div&gt;&lt;div&gt;15:10-16:10 &amp;nbsp;Transcriptomics example: data in 2 x2 contingency table, p-value calculation performed and interpreted.&lt;/div&gt;&lt;div&gt;16:11-18:07 &amp;nbsp;Caveats for using and interpreting the p-value of overlap statistic in IPA.&lt;/div&gt;&lt;div&gt;18:08-18:36 &amp;nbsp;Where to find more information about IPA and Customer Support information.&lt;/div&gt;&lt;/p&gt;&lt;p&gt;&lt;a href="http://tv.qiagenbioinformatics.com/photo/19605716/understanding-the-p-value-of"&gt;&lt;img src="http://tv.qiagenbioinformatics.com/19476794/19605716/3f010f6e26d0f172f765bc2ed547ff43/standard/download-2-thumbnail.jpg" width="600" height="338"/&gt;&lt;/a&gt;&lt;/p&gt;</description>
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            <pubDate>Fri, 27 Jun 2025 21:28:20 GMT</pubDate>
            <media:title>Understanding the P-Value of Overlap Statistic in IPA</media:title>
            <itunes:summary>Learn how to interpret your p-value of overlaps results in IPA. You can gain a deeper understanding of the right-tailed Fisher’s Exact Test, why it’s used in IPA, how the results are calculated, and caveats to keep in mind when interpreting your results.For more information visitour websiteSections:0:00-1:09 Introduction to the video. The two types of p-values that are relevant for IPA and how they differ.1:09-2:25 History of the Fisher’s Exact Test: the “Lady Tasting Tea” experiment.2:25-5:50 Hypothesis testing for enrichment in IPA. The reference set, the null hypothesis used, and the overlap of molecules defined.5:51-7:58 Why the right-tailed Fisher’s Exact Test is used in IPA.7:58- 8:41 Explanation of sampling and expected proportions from the hypergeometric distribution.8:41-9:34 Defining significance levels in the distribution. Why only the right-tailed, rather than two-tailed test, is considered in IPA.9:35-11:04 The p-value defined and default significance level used in IPA.11:04-11:12 How the p-value is calculated. How data is entered into the 2 x 2 contingency table and the formula used.11:13-13:34 Example calculation and interpretation using the “Lady Tasting Tea” experimental data. Why the p-value of overlap calculations are Exact.13:35-15:09 Transcriptomics example: Number of molecules tested and how they are categorized.15:10-16:10 Transcriptomics example: data in 2 x2 contingency table, p-value calculation performed and interpreted.16:11-18:07 Caveats for using and interpreting the p-value of overlap statistic in IPA.18:08-18:36 Where to find more information about IPA and Customer Support information.</itunes:summary>
            <itunes:subtitle>Learn how to interpret your p-value of overlaps results in IPA. You can gain a deeper understanding of the right-tailed Fisher’s Exact Test, why it’s used in IPA, how the results are calculated, and caveats to keep in mind when interpreting your...</itunes:subtitle>
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            <itunes:duration>18:37</itunes:duration>
            <media:description type="html">&lt;p&gt;Learn how to interpret your p-value of overlaps results in IPA. You can gain a deeper understanding of the right-tailed Fisher’s Exact Test, why it’s used in IPA, how the results are calculated, and caveats to keep in mind when interpreting your results.&lt;br&gt;For more information visit&amp;nbsp;our &lt;a href="https://www.qiagenbioinformatics.com/products/ingenuity-pathway-analysis/?cmpid=BIOX_WEB_BioX_20191605_tv.qiagenbioinformatics_Webinar_BioxBA_Must_Win_1_BIOX"&gt;&lt;u&gt;&lt;b&gt;website&lt;/b&gt;&lt;/u&gt;&lt;/a&gt;&lt;br&gt;&lt;br&gt;Sections:&lt;br&gt;&lt;div&gt;0:00-1:09 &amp;nbsp;Introduction to the video. The two types of p-values that are relevant for IPA and how they differ.&lt;/div&gt;&lt;div&gt;1:09-2:25 &amp;nbsp;History of the Fisher’s Exact Test: the “Lady Tasting Tea” experiment.&lt;/div&gt;&lt;div&gt;2:25-5:50 &amp;nbsp;Hypothesis testing for enrichment in IPA. The reference set, the null hypothesis used, and the overlap of molecules defined.&lt;/div&gt;&lt;div&gt;5:51-7:58 &amp;nbsp;Why the right-tailed Fisher’s Exact Test is used in IPA.&lt;/div&gt;&lt;div&gt;7:58- 8:41 &amp;nbsp;Explanation of sampling and expected proportions from the hypergeometric distribution.&lt;/div&gt;&lt;div&gt;8:41-9:34 &amp;nbsp;Defining significance levels in the distribution. Why only the right-tailed, rather than two-tailed test, is considered in IPA.&lt;/div&gt;&lt;div&gt;9:35-11:04 &amp;nbsp;The p-value defined and default significance level used in IPA.&lt;/div&gt;&lt;div&gt;11:04-11:12 &amp;nbsp;How the p-value is calculated. &amp;nbsp;How data is entered into the 2 x 2 contingency table and the formula used.&lt;/div&gt;&lt;div&gt;11:13-13:34 &amp;nbsp;Example calculation and interpretation using the “Lady Tasting Tea” experimental data. Why the p-value of overlap calculations are Exact.&lt;/div&gt;&lt;div&gt;13:35-15:09 &amp;nbsp;Transcriptomics example: Number of molecules tested and how they are categorized.&lt;/div&gt;&lt;div&gt;15:10-16:10 &amp;nbsp;Transcriptomics example: data in 2 x2 contingency table, p-value calculation performed and interpreted.&lt;/div&gt;&lt;div&gt;16:11-18:07 &amp;nbsp;Caveats for using and interpreting the p-value of overlap statistic in IPA.&lt;/div&gt;&lt;div&gt;18:08-18:36 &amp;nbsp;Where to find more information about IPA and Customer Support information.&lt;/div&gt;&lt;/p&gt;&lt;p&gt;&lt;a href="http://tv.qiagenbioinformatics.com/photo/19605716/understanding-the-p-value-of"&gt;&lt;img src="http://tv.qiagenbioinformatics.com/19476794/19605716/3f010f6e26d0f172f765bc2ed547ff43/standard/download-2-thumbnail.jpg" width="600" height="338"/&gt;&lt;/a&gt;&lt;/p&gt;</media:description>
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            <category>Fisher’s Exact Test</category>
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            <category>ingenuity pathway analysis</category>
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            <category>IPA Fisher’s Exact Test</category>
            <category>ipa tutorial</category>
            <category>p-value</category>
            <category>p-value of overlap</category>
            <category>p-value p-value of overlap</category>
            <category>reference set</category>
            <category>right-tailed Fisher’s Exact Test</category>
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